Psychological changes with recombinant human erythropoietin therapy in hemodialysis patients.

Does recombinant human erythropoietin affect plasma lipids in hemodialysis patients?

Prof. Dr. Kuddusi Cengiz, Ondokuz Mayis University School of Medicine, Department of Nephrology, TR-55139 Samsun (Turkey) Dear Sir, The correction of anemia in hemodialysis patients with human recombinant erythropoietin increases appetite, anabolic effects, and improves physical, psychological activities and endocrine functions. As the sense of well-being improves, the patients increase food in...

Subcutaneous versus intravenous recombinant human erythropoietin administration in hemodialysis patients.

Hemodynamic and hormonal changes during erythropoietin therapy in hemodialysis patients.

To better understand the mechanism of recombinant human erythropoietin (rhEPO)-induced increase in BP, hemodynamic parameters, body fluid volumes, and the hormones implicated in BP regulation were studied in 32 anemic hemodialysis patients before and after 3 to 4 mo of rhEPO therapy. Hemoglobin levels increased from 83 +/- 1.5 to 119 +/- 2.3 g/L (P < 0.01) after rhEPO therapy (25 to 43 U/kg) ad...

Neutrophil activation and resistance to recombinant human erythropoietin therapy in hemodialysis patients.

AIM The aim of this work was to evaluate the neutrophil activation state in chronic kidney disease (CKD) patients under hemodialysis, and its linkage with resistance to recombinant human erythropoietin (rhEPO) therapy. METHODS We studied 63 CKD patients under hemodialysis and rhEPO treatment (32 responders and 31 non-responders to rhEPO therapy). In 20 of the CKD patients (10 responders and 1...

Hemodynamic changes by recombinant erythropoietin therapy in hemodialyzed patients.

Recombinant human erythropoietin therapy was given to 15 patients undergoing long-term hemodialysis with normal cardiac function. None of the patients had hypertension before the erythropoietin therapy and had received no antihypertensive agents. Before and after the erythropoietin therapy M-mode and pulsed Doppler echocardiographic studies, measurements of plasma volume by radioiodinated human...